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OSX has a built in Mail application, that's what he needs to use. He needs to open up that mail application and set it up to connect to his account. If he doesn't know how to do that then he needs to either look on the University's web site or contact their help desk.
Although I can't really be specific about the settings he needs to use, I can offer a best guess. He could try setting up the program to use mail.domain.edu or domain.edu where domain.edu = the domain name of the school. Then set it up for authentication, and have him use his University login and password. That's the most common setup and might work, but ultimately he's probably going to have to contact the help desk to get the correct information.